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Literature summary for 6.3.2.17 extracted from

  • Smith, C.A.; Cross, J.A.; Bognar, A.L.; Sun, X.
    Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops (2006), Acta Crystallogr. Sect. D, 62, 548-558.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21 Lacticaseibacillus casei

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method using 50 mM acetate buffer pH 5.3 and 6% PEG 4000 Lacticaseibacillus casei

Protein Variants

Protein Variants Comment Organism
G51S no FGPS activity Lacticaseibacillus casei
G51S/S52T no FGPS activity Lacticaseibacillus casei
S73A mutant retains some FGPS activity Lacticaseibacillus casei

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ essential Lacticaseibacillus casei

Organism

Organism UniProt Comment Textmining
Lacticaseibacillus casei P15925
-
-

Purification (Commentary)

Purification (Comment) Organism
chitin column chromatography Lacticaseibacillus casei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
Lacticaseibacillus casei ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
?

Synonyms

Synonyms Comment Organism
Folylpolyglutamate synthetase
-
Lacticaseibacillus casei
FPGS
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Lacticaseibacillus casei