Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli and Saccharomyces cerevisiae | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | removal of the first 16 or 40 residues of the protein abolishes the enzyme activity in the yeast cell host, Saccharomyces cerevisiae but not in Escherichia coli | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
3D7, K1, Tak9, M24, K39, HB3, W282, V1/S, Dd2 and FCB lines | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the expression of the enzyme in Escherichia coli and Saccharomyces cerevisiae defective strains restores Escherichia coli cells to methionine and glycine prototrophy on minimal medium, but cannot entirely compensate for the loss of the native homologue in Saccharomyces cerevisiae. The malarial gene encodes a protein carrying dihydrofolate synthetase and folylpolyglutamate synthetase activities, both needed for the de novo folate synthesis | Plasmodium falciparum | ? | - |
? |