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Literature summary for 6.3.2.17 extracted from

  • Rots, M.G.; Pieters, R.; Peters, G.J.; Noordhuis, P.; van Zantwijk, C.H.; Kaspers, G.J.; Hahlen, K.; Creutzig, U.; Veerman, A.J.; Jansen, G.
    Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia (1999), Blood, 93, 1677-1683.
    View publication on PubMed
Search for more literature for 6.3.2.17

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 human, children
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Homo sapiens
-
peripheral blood
-
 Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000001
-
 patients with acute myeloid leukemia, AML Homo sapiens
0.000000099
-
 patients with T-linage acute lymphoblastic leukemia, T-ALL Homo sapiens
0.000000244
-
 patients with c/preB-acute lymphoblastic leukemia, c/preB-ALL Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + methotrexate-Glu + L-glutamate T-ALL and AML patients show inefficient polyglutamylation due to lower enzyme activity Homo sapiens ADP + methotrexate-Glu2 + phosphate
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 ?