Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Reducing agents | absolutely dependent on | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00081 | - |
7,8-dihydropteroyl-Glu | - |
Homo sapiens | |
0.0014 | - |
5,6,7,8-tetrahydropteroyl-Glu3 | - |
Homo sapiens | |
0.0016 | - |
5,6,7,8-tetrahydropteroyl-Glu4 | - |
Homo sapiens | |
0.0027 | - |
5,6,7,8-tetrahydropteroyl-Glu5 | 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | Homo sapiens | |
0.0033 | - |
5,6,7,8-tetrahydropteroyl-Glu2 | - |
Homo sapiens | |
0.0037 | - |
10-formyl-5,6,7,8-tetrahydropteroyl-Glu | - |
Homo sapiens | |
0.0044 | - |
5,6,7,8-tetrahydropteroyl-Glu | aminopterin | Homo sapiens | |
0.012 | - |
7,8-dihydropteroyl-(4-aminobutanoyl)-Glu | pteroyl-Glu4 | Homo sapiens | |
0.013 | - |
5-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
Homo sapiens | |
0.016 | - |
pteroyl-Glu2 | - |
Homo sapiens | |
0.02 | - |
methotrexate-Glu3 | pteroyl-Glu3 | Homo sapiens | |
0.048 | - |
7,8-dihydropteroyl-Glu2 | - |
Homo sapiens | |
0.059 | - |
pteroyl-Glu | - |
Homo sapiens | |
0.064 | - |
pteroyl-Glu5 | - |
Homo sapiens | |
0.105 | - |
5-formyl-5,6,7,8-tetrahydropteroyl-Glu | - |
Homo sapiens | |
0.2 | - |
L-Glu | MgATP2- | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | maximal activity at 20 mM | Homo sapiens | |
K+ | required form maximal activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
61000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.31 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
0-4°C, stable for several days, or at -20°C for longer periods | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphate + 7,8-dihydropteroyl-Glu | - |
Homo sapiens | ATP + 7,8-dihydropteroate + L-glutamate | - |
? | |
ATP + (6S)-5,6,7,8-tetrahydropteroylglutamate + L-glutamate | - |
Homo sapiens | ADP + phosphate + (6S)-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate | - |
Homo sapiens | ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glu3 + L-glutamate | - |
Homo sapiens | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu4 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glu5 + L-glutamate | - |
Homo sapiens | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu6 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu | - |
Homo sapiens | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Homo sapiens | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2 | - |
? | |
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate | - |
Homo sapiens | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 7,8-dihydropteroyl-(4-aminobutanoyl)-Glu + L-glutamate | - |
Homo sapiens | ADP + phosphate + 7,8-dihydropteroyl-(4-aminobutanoyl)-Glu2 | - |
? | |
ATP + 7,8-dihydropteroyl-Glu + L-glutamate | - |
Homo sapiens | ADP + phosphate + 7,8-dihydropteroyl-Glu2 | - |
? | |
ATP + methotrexate + L-glutamate | - |
Homo sapiens | ADP + phosphate + methotrexyl-Glu | - |
? | |
ATP + pteroyl-Glu + Glu | - |
Homo sapiens | ADP + phosphate + pteroylmonoglutamyl-Glu | - |
? | |
ATP + pteroyl-Glu3 + L-glutamate | - |
Homo sapiens | ADP + phosphate + pteroyl-Glu4 | - |
? | |
ATP + pteroyl-Glu4 + L-glutamate | - |
Homo sapiens | ADP + phosphate + pteroyl-Glu5 | - |
? | |
ATP + pteroyl-Glu5 + L-glutamate | - |
Homo sapiens | ADP + phosphate + pteroyl-Glu6 | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 61000, SDS-PAGE | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens | |
0.01 | - |
pteroyl-Glu5 | - |
Homo sapiens | |
0.34 | - |
pteroyl-Glu4 | - |
Homo sapiens | |
0.55 | - |
pteroyl-Glu3 | - |
Homo sapiens | |
0.65 | - |
pteroyl-Glu | - |
Homo sapiens | |
0.81 | - |
5,6,7,8-tetrahydropteroyl-Glu2 | - |
Homo sapiens | |
0.82 | - |
pteroyl-Glu2 | - |
Homo sapiens | |
0.84 | - |
7,8-dihydropteroyl-Glu | - |
Homo sapiens | |
0.95 | - |
7,8-dihydropteroyl-Glu2 | - |
Homo sapiens | |
0.99 | - |
5,6,7,8-tetrahydropteroyl-Glu | - |
Homo sapiens | |
1.17 | - |
aminopterin | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.6 | - |
- |
Homo sapiens |