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Literature summary for 6.3.2.17 extracted from

  • Atkinson, I.; Garrow, T.; Brenner, A.; Shane, B.
    Human cytosolic folylpoly-gamma-glutamate synthase (1997), Methods Enzymol., 281, 134-140.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Reducing agents absolutely dependent on Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00081
-
7,8-dihydropteroyl-Glu
-
Homo sapiens
0.0014
-
5,6,7,8-tetrahydropteroyl-Glu3
-
Homo sapiens
0.0016
-
5,6,7,8-tetrahydropteroyl-Glu4
-
Homo sapiens
0.0027
-
5,6,7,8-tetrahydropteroyl-Glu5 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 Homo sapiens
0.0033
-
5,6,7,8-tetrahydropteroyl-Glu2
-
Homo sapiens
0.0037
-
10-formyl-5,6,7,8-tetrahydropteroyl-Glu
-
Homo sapiens
0.0044
-
5,6,7,8-tetrahydropteroyl-Glu aminopterin Homo sapiens
0.012
-
7,8-dihydropteroyl-(4-aminobutanoyl)-Glu pteroyl-Glu4 Homo sapiens
0.013
-
5-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
Homo sapiens
0.016
-
pteroyl-Glu2
-
Homo sapiens
0.02
-
methotrexate-Glu3 pteroyl-Glu3 Homo sapiens
0.048
-
7,8-dihydropteroyl-Glu2
-
Homo sapiens
0.059
-
pteroyl-Glu
-
Homo sapiens
0.064
-
pteroyl-Glu5
-
Homo sapiens
0.105
-
5-formyl-5,6,7,8-tetrahydropteroyl-Glu
-
Homo sapiens
0.2
-
L-Glu MgATP2- Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ maximal activity at 20 mM Homo sapiens
K+ required form maximal activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.31
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
0-4°C, stable for several days, or at -20°C for longer periods Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + 7,8-dihydropteroyl-Glu
-
Homo sapiens ATP + 7,8-dihydropteroate + L-glutamate
-
?
ATP + (6S)-5,6,7,8-tetrahydropteroylglutamate + L-glutamate
-
Homo sapiens ADP + phosphate + (6S)-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate
-
Homo sapiens ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glu3 + L-glutamate
-
Homo sapiens ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu4
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glu5 + L-glutamate
-
Homo sapiens ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu6
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu
-
Homo sapiens ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Homo sapiens ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
?
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate
-
Homo sapiens ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 7,8-dihydropteroyl-(4-aminobutanoyl)-Glu + L-glutamate
-
Homo sapiens ADP + phosphate + 7,8-dihydropteroyl-(4-aminobutanoyl)-Glu2
-
?
ATP + 7,8-dihydropteroyl-Glu + L-glutamate
-
Homo sapiens ADP + phosphate + 7,8-dihydropteroyl-Glu2
-
?
ATP + methotrexate + L-glutamate
-
Homo sapiens ADP + phosphate + methotrexyl-Glu
-
?
ATP + pteroyl-Glu + Glu
-
Homo sapiens ADP + phosphate + pteroylmonoglutamyl-Glu
-
?
ATP + pteroyl-Glu3 + L-glutamate
-
Homo sapiens ADP + phosphate + pteroyl-Glu4
-
?
ATP + pteroyl-Glu4 + L-glutamate
-
Homo sapiens ADP + phosphate + pteroyl-Glu5
-
?
ATP + pteroyl-Glu5 + L-glutamate
-
Homo sapiens ADP + phosphate + pteroyl-Glu6
-
?

Subunits

Subunits Comment Organism
monomer 1 * 61000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens
0.01
-
pteroyl-Glu5
-
Homo sapiens
0.34
-
pteroyl-Glu4
-
Homo sapiens
0.55
-
pteroyl-Glu3
-
Homo sapiens
0.65
-
pteroyl-Glu
-
Homo sapiens
0.81
-
5,6,7,8-tetrahydropteroyl-Glu2
-
Homo sapiens
0.82
-
pteroyl-Glu2
-
Homo sapiens
0.84
-
7,8-dihydropteroyl-Glu
-
Homo sapiens
0.95
-
7,8-dihydropteroyl-Glu2
-
Homo sapiens
0.99
-
5,6,7,8-tetrahydropteroyl-Glu
-
Homo sapiens
1.17
-
aminopterin
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.6
-
-
Homo sapiens