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Literature summary for 6.3.2.12 extracted from
- Co-purification of dihydrofolate synthetase and N-10formyltetrahydropteroyldiglutamate synthetase from E. coli (1983), Adv. Exp. Med. Biol., 163, 167-181.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition by 10N-formyltetrahydropteroyldiglutamate | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | monovalent cation required | Escherichia coli |  |
| K+ | monovalent cation requirement is satisfied by K+, Rb+ or NH4+ | Escherichia coli | |
| NH4+ | monovalent cation requirement is satisfied by K+, Rb+ or NH4+ | Escherichia coli | |
| Rb+ | monovalent cation requirement is satisfied by K+, Rb+ or NH4+ | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
enzyme posseses dihydrofolate synthetase and N10-formyltetrahydropteroyldiglutamate synthetase activity | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 7,8-dihydropteroate + L-Glu | - |
Escherichia coli | ADP + phosphate + 7,8-dihydrofolate | - |
? | |
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