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Literature summary for 6.3.2.12 extracted from
- Bacterial folylpoly(gamma-glutamate) synthase-dihydrofolate synthase (1986), Methods Enzymol., 122, 349-359.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | 5,6,7,8-tetrahydrofolate does not significantly inhibit | Corynebacterium sp. |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0029 | - |
ATP | - |
Corynebacterium sp. |  |
| 1.38 | - |
L-Glu | - |
Corynebacterium sp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51000 | - |
gel filtration | Corynebacterium sp. |
| 53000 | - |
1 * 53000, SDS-PAGE | Corynebacterium sp. |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium sp. | - |
enzyme posseses both dihydrofolate synthetase activity and folylpolyglutamate synthetase activity | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Corynebacterium sp. |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Corynebacterium sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 7,8-dihydropteroate + L-Glu | - |
Corynebacterium sp. | ADP + phosphate + 7,8-dihydrofolate | - |
? | |
| ATP + 7,8-dihydropteroate + L-glutamate | ATP in form of MgATP2- | Corynebacterium sp. | ADP + phosphate + 7,8-dihydropteroylglutamate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 53000, SDS-PAGE | Corynebacterium sp. |
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