Literature summary for 6.3.2.10 extracted from

Comess, K.M.; Schurdak, M.E.; Voorbach, M.J.; Coen, M.; Trumbull, J.D.; Yang, H.; Gao, L.; Tang, H.; Cheng, X.; Lerner, C.G.; McCall, J.O.; Burns, D.J.; Beutel, B.A.
An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF (2006), J. Biomol. Screen., 11, 743-754.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Streptococcus pneumoniae

Inhibitors

Inhibitors	Comment	Organism	Structure
2,4-dichloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-5-(morpholin-4-ylsulfonyl)benzamide	-	Streptococcus pneumoniae
2-(propylamino)ethyl 4-amino-3-propoxybenzoate	-	Streptococcus pneumoniae
2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)-5-[(diethylamino)sulfonyl]benzamide	-	Streptococcus pneumoniae
2-thioxo-3-[4-(trifluoromethoxy)phenyl]-2,3-dihydroquinazolin-4(1H)-one	-	Streptococcus pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae	-	-	-

Synonyms

Synonyms	Comment	Organism
MurF	-	Streptococcus pneumoniae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.001	-	-	Streptococcus pneumoniae	2,4-dichloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-5-(morpholin-4-ylsulfonyl)benzamide
0.008	-	-	Streptococcus pneumoniae	2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)-5-[(diethylamino)sulfonyl]benzamide
0.019	-	-	Streptococcus pneumoniae	2-thioxo-3-[4-(trifluoromethoxy)phenyl]-2,3-dihydroquinazolin-4(1H)-one
0.03	-	-	Streptococcus pneumoniae	2-(propylamino)ethyl 4-amino-3-propoxybenzoate

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Release 2023.1 (January 2023)