Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | ASNS is induced by ATF4, amino acid deprivation, or ER stress, siRNA-mediated knockdown of CHOP further enhances the induction of ASNS by either amino acid deprivation or ER stress, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression analysis in HEK-293 cells in response to ATF4 or CHOP | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CHOP suppresses the induction of the endogenous ASNS gene and inhibits transcription from a reporter gene driven by the ASNS promoter following activation by ATF4 or amino acid deprivation. The inhibitory effect of CHOP on the ASNS gene is not observed when truncated proteins, encoding either the N- or C-terminal portion of the protein, are expressed, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ASNS | - |
Homo sapiens |
Asparagine synthetase | - |
Homo sapiens |