Literature summary for 6.3.1.2 extracted from

Fernandes, S.P.; Dringen, R.; Lawen, A.; Robinson, S.R.
Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron (2011), Neurosci. Lett., 490, 27-30.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ascorbate	little loss of activity with 2 mM ascorbate alone. Complete inactivation by co-incubation with 1 mM H2O2, 0.002 mM Fe3+, 2 mM ascorbate for 30 min	Ovis aries
Fe3+	no loss of activity with 0.002 mM Fe3+ alone. Complete inactivation by co-incubation with 1 mM H2O2, 0.002 mM Fe3+, 2 mM ascorbate for 30 min	Ovis aries
H2O2	1 mM, 3 h, 63% loss of activity. Inactivation is prevented by the iron chelators 2,2'-dipyridylor 1,10-phenanthroline, but not by their non-chelating analogues	Mus musculus
H2O2	1 mM, 30 min, 41% loss of activity. Complete inactivation by co-incubation with 1 mM H2O2, 0.002 mM Fe3+, 2 mM ascorbate for 30 min	Ovis aries

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Ovis aries	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	primary cell culture	Mus musculus	-
brain	-	Ovis aries	-

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Release 2023.1 (January 2023)