Literature summary for 6.3.1.2 extracted from

Occhipinti, A.; Berlicki, L.; Giberti, S.; Dziedziola, G.; Kafarski, P.; Forlani, G.
Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase (2010), Pest Manag. Sci., 66, 51-58.

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Inhibitors

Inhibitors	Comment	Organism	Structure
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)	non-competitive mechanism against glutamate and uncompetitive mechanism against ATP	Zea mays
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)	non-competitive mechanism against glutamate and uncompetitive mechanism against ATP	Zea mays
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)	non-competitive mechanism against glutamate and uncompetitive mechanism against ATP	Zea mays
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)	non-competitive mechanism against glutamate and uncompetitive mechanism against ATP	Zea mays
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)	non-competitive mechanism against glutamate and uncompetitive mechanism against ATP	Zea mays

Organism

Organism	UniProt	Comment	Textmining
Zea mays	P38561	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0076	-	-	Zea mays	[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0128	-	-	Zea mays	[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.015	-	-	Zea mays	[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.021	-	-	Zea mays	[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0212	-	-	Zea mays	[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

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Release 2023.1 (January 2023)