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Literature summary for 6.3.1.2 extracted from

  • Bioulac-Sage, P.; Laumonier, H.; Rullier, A.; Cubel, G.; Laurent, C.; Zucman-Rossi, J.; Balabaud, C.
    Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology (2008), Liver Int., 29, 459-465.
    View publication on PubMed
Search for more literature for 6.3.1.2

Application

Application Comment Organism
diagnostics glutamine synthetase is a useful marker in tumour liver pathology, including hepatocellular adenomas and nodules in cirrhosis. Enzyme overexpression in focal nodular hyperplasia can be used as easy diagnostic tool in surgical pathology Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Homo sapiens
-
 ADP + phosphate + L-glutamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell the enzyme expression pattern is completely different form the healthy cell pattern and appears diffuse and not map-like Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
liver the cytosolic enzyme is localized in large areas, anastomosed in a map-like pattern, often surrounding hepatic veins, whereas GS is not expressed in hepatocytes close to fibrotic bands containing arteries and ductules Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
 Homo sapiens ADP + phosphate + L-glutamine
-
 ?

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens