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Literature summary for 6.3.1.2 extracted from
- Role of endothelins as mediators of injury-induced alterations of glial glutamate turnover (2008), J. Neurosci. Res., 86, 660-667.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibitory effects of endothelins on the expression of glutamine synthetase, cultured cortical astrocytes maintained with endothelins show an almost complete loss of glutamine synthetase, this coordinated inhibition of astroglial glutamate uptake and turnover, e.g. by ET-1, dissociates when extracellular glutamate concentrations increase, overview | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-glutamate + NH3 | Rattus norvegicus | brain injuries are usually associated with an increase in the expression of the glutamate-converting enzyme glutamine synthetase | ADP + phosphate + L-glutamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | cultured cortical astrocytes maintained with endothelins show an almost complete loss of glutamine synthetase | Rattus norvegicus | - |
| astroglial cell | - |
Rattus norvegicus | - |
| brain | cerebral cortex | Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-glutamate + NH3 | - |
Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
| ATP + L-glutamate + NH3 | brain injuries are usually associated with an increase in the expression of the glutamate-converting enzyme glutamine synthetase | Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Glutamine synthetase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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