Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | ATP treatment decreases glutamine synthetase activities and protein expression | Rattus norvegicus | |
additional information | 3'-O-(4-benzoylbenzoyl)-ATP suppresses the enzyme expression. Removal of extracellular Ca2+ and inhibition of protein kinase C restores the ATP-decreased enzyme expression but fails to restore the P2X7-decreased L-glutamate uptake | Rattus norvegicus | |
P2X7 receptor | stimulation of P2X7 receptors for 2 h inhibits both activity and protein expression of glutamine synthetase, periodate-oxidized 2',3'-dialdehyde ATP abolishes the inhibition | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | Rattus norvegicus | enzyme regulation involving L-glutamate uptake, Ca2+, and P2X7 receptors, overview | ADP + phosphate + L-glutamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | primary | Rattus norvegicus | - |
RBA-2 cell | a rat brain-derived type-2 astrocyte cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | - |
Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
ATP + L-glutamate + NH3 | enzyme regulation involving L-glutamate uptake, Ca2+, and P2X7 receptors, overview | Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutamine synthetase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |