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Literature summary for 6.3.1.2 extracted from

  • Lo, J.; Huang, W.; Chou, Y.; Tseng, C.; Lee, W.; Sun, S.H.
    Activation of P2X7 receptors decreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms (2008), J. Neurochem., 105, 151-164.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ATP ATP treatment decreases glutamine synthetase activities and protein expression Rattus norvegicus
additional information 3'-O-(4-benzoylbenzoyl)-ATP suppresses the enzyme expression. Removal of extracellular Ca2+ and inhibition of protein kinase C restores the ATP-decreased enzyme expression but fails to restore the P2X7-decreased L-glutamate uptake Rattus norvegicus
P2X7 receptor stimulation of P2X7 receptors for 2 h inhibits both activity and protein expression of glutamine synthetase, periodate-oxidized 2',3'-dialdehyde ATP abolishes the inhibition Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Rattus norvegicus enzyme regulation involving L-glutamate uptake, Ca2+, and P2X7 receptors, overview ADP + phosphate + L-glutamine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary Rattus norvegicus
-
RBA-2 cell a rat brain-derived type-2 astrocyte cell line Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
Rattus norvegicus ADP + phosphate + L-glutamine
-
?
ATP + L-glutamate + NH3 enzyme regulation involving L-glutamate uptake, Ca2+, and P2X7 receptors, overview Rattus norvegicus ADP + phosphate + L-glutamine
-
?

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus