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Literature summary for 6.3.1.2 extracted from

  • Poyck, P.P.; Hoekstra, R.; Vermeulen, J.L.; van Wijk, A.C.; Chamuleau, R.A.; Hakvoort, T.B.; van Gulik, T.M.; Lamers, W.H.
    Expression of glutamine synthetase and carbamoylphosphate synthetase I in a bioartificial liver: markers for the development of zonation in vitro (2008), Cells Tissues Organs, 188, 259-269.
    View publication on PubMed
Search for more literature for 6.3.1.2

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Sus scrofa glutamine synthetase catalyzes the ATP-dependent conversion of ammonia and glutamate to glutamine in the pericentral zone ADP + phosphate + L-glutamine
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa P46410
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte glutamine synthetase protein is preferentially expressed in hepatocytes adjacent to oxygen-supplying capillaries and in previously CPS-positive hepatocytes. No shift towards a periportal or pericentral phenotype, overview Sus scrofa
-
liver dynamic expression pattern of the enzyme in hepatocytes of different zones of the liver lobule, overview Sus scrofa
-
additional information mechanism underlying metabolic zonation, overview Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
 Sus scrofa ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 glutamine synthetase catalyzes the ATP-dependent conversion of ammonia and glutamate to glutamine in the pericentral zone Sus scrofa ADP + phosphate + L-glutamine
-
 ?

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Sus scrofa