Literature summary for 6.3.1.2 extracted from

Matthews, G.D.; Gould, R.M.; Vardimon, L.
A single glutamine synthetase gene produces tissue-specific subcellular localization by alternative splicing (2005), FEBS Lett., 579, 5527-5534.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	neural enzyme is retained in the cytoplasm. Two different glutamine synthetase transcripts are generated by tissue-specific alternative splicing. The liver transcript contains an alternative exon that is not present in the neural one	Squalus acanthias	5737	-
mitochondrion	liver enzyme is targeted to mitochondria. Two different glutamine synthetase transcripts are generated by tissue-specific alternative splicing. The liver transcript contains an alternative exon that is not present in the neural one. This exon leads to acquisition of an upstream in-frame start codon and formation of a mitochondrial targeting signal	Squalus acanthias	5739	-

Organism

Organism	UniProt	Comment	Textmining
Squalus acanthias	P41320	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	liver enzyme is targeted to mitochondria. Two different glutamine synthetase transcripts are generated by tissue-specific alternative splicing. The liver transcript contains an alternative exon that is not present in the neural one. This exon leads to acquisition of an upstream in-frame start codon and formation of a mitochondrial targeting signal	Squalus acanthias	-
spinal cord	neural enzyme is retained in the cytoplasm. Two different glutamine synthetase transcripts are generated by tissue-specific alternative splicing. The liver transcript contains an alternative exon that is not present in the neural one	Squalus acanthias	-

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Release 2023.1 (January 2023)