Literature summary for 6.3.1.2 extracted from

Hammarstrom, A.; Soliman, A.; Nordlund, S.
Low- and high-activity forms of glutamine synthetase from Rhodospirillum rubrum: sensitivity to feed-back effectors and activation of the low-activity form (1991), Biochim. Biophys. Acta, 1080, 259-263.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Ala	-	Rhodospirillum rubrum
AMP	-	Rhodospirillum rubrum
CTP	-	Rhodospirillum rubrum
Gly	-	Rhodospirillum rubrum
His	-	Rhodospirillum rubrum
UTP	-	Rhodospirillum rubrum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	activity of the low-activity form is higher than that of the high-activity form in the Mn2+-dependent biosynthetic assay	Rhodospirillum rubrum

Organism

Organism	UniProt	Comment	Textmining
Rhodospirillum rubrum	-	two enzyme forms: low-activity form and high-activity form, depending on the concentration of combined nitrogen in the medium before harvest	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-Glu + NH4+	-	Rhodospirillum rubrum	ADP + phosphate + L-Gln	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	low activity and high activity enzyme form, Mn2+-activated	Rhodospirillum rubrum
7.4	-	low activity and high activity enzyme form, Mg2+-activated	Rhodospirillum rubrum

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Release 2023.1 (January 2023)