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Literature summary for 6.2.1.7 extracted from
- Determination of the mechanism of reaction for bile acid:CoA ligase (1994), Biochem. J., 304, 945-949.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | competitive versus ATP | Cavia porcellus |  |
| choloyl-CoA | uncompetitive versus CoA | Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA | bi uni uni bi ping-pong mechanism with ATP binding first, random release of the final products | Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + cholate + CoA | - |
Cavia porcellus | AMP + diphosphate + choloyl-CoA | - |
? | |
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