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Literature summary for 6.2.1.45 extracted from

  • Lambert-Smith, I.; Saunders, D.; Yerbury, J.
    The pivotal role of ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration (2020), Int. J. Biochem. Cell Biol., 123, 105746.
    View publication on PubMed
Search for more literature for 6.2.1.45

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
117849
-
 calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Homo sapiens
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22314
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme (UBA1) exhibits ubiquitous expression throughout all human tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Homo sapiens AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
Uba1
-
 Homo sapiens
UBE1
-
 Homo sapiens
ubiquitin-activating enzyme E1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction impaired UBA1 activity in a range of neurodegenerative conditions, including Parkinson's disease, Alzheimer's disease, Huntington's disease and spinal muscular atrophy Homo sapiens
metabolism ubiquitin-activating enzyme E1, UBA1, functions at the apex of the enzymatic ubiquitylation cascade, catalysing ubiquitin activation. UBA1 is thus of fundamental importance to the modulation of ubiquitin homeostasis and to all downstream ubiquitylation-dependent cellular processes, including proteolysis through the ubiquitin-proteasome system and selective autophagy Homo sapiens
physiological function UBA1 is essential for autophagy in certain cell types Homo sapiens