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Literature summary for 6.2.1.45 extracted from
- Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants (2022), Cell. Mol. Life Sci., 79, 192.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TAK-243 | i.e. MLN7243 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P22314 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| E1 ubiquitin-activating enzyme | - |
Homo sapiens |
| Uba1 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000001 | - |
pH and temperature not specified in the publication | Homo sapiens | TAK-243 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme regulates the ubiquitin conjugation cascade | Homo sapiens |
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