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Literature summary for 6.2.1.45 extracted from

  • Zhang, L.; Zhao, Z.; Wang, Y.; Li, N.; Cao, N.; Yang, L.
    Changes in expression of interferon-stimulated genes and ubiquitin activating enzyme E1-like in ovine thymus during early pregnancy (2020), Anim. Reprod., 17, e20190134 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.45

Cloned(Commentary)

Cloned (Comment) Organism
gene UBA1, real-time quantitative PCR enzyme expression analysis Ovis aries

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Ovis aries
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries A0A6P7D3I5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus ovine thymuses are sampled on day 16 of the estrous cycle and on days 13, 16 and 25 of gestation, and UBE1L is detected by real-time quantitative PCR, Western blot and immunohistochemistry. The expression of UBE1L is declined during early pregnancy Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Ovis aries AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
UBA7
-
 Ovis aries
UBE1L
-
 Ovis aries
ubiquitin activating enzyme E1-like
-
 Ovis aries
ubiquitin-like modifier-activating enzyme 7 isoform X2 UniProt Ovis aries

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Ovis aries

Expression

Organism Comment Expression
Ovis aries expression of UBE1L declines during early pregnancy down

General Information

General Information Comment Organism
metabolism early pregnancy influences expression of STAT1, Mx1, IP-10 and UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep Ovis aries
physiological function early pregnancy reduces expression of UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep Ovis aries