Any feedback?
Literature summary for 6.2.1.45 extracted from
- Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo (2000), Eur. J. Biochem., 267, 3712-3722.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A31N-ts20 cell | mouse embryo fibroblast cell, thermosensitive for ubiquitin-activating enzyme E1 | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| E1 ubiquitin-activating enzyme | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in mouse embryo fibroblast cell A31N-ts20, which is thermosensitive for ubiquitin-activating enzyme E1, the enzymatic activity of the enzyme is heat-inactivatable in vitro; and a major mechanism responsible for E1 inactivation in vivo consists of accelerated destruction. In vivo, ubiquitination of the various protein substrates in A31N-ts20 cells requires different amounts of E1 enzyme | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
