Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.2.1.3 extracted from

  • Teodoro, B.G.; Sampaio, I.H.; Bomfim, L.H.; Queiroz, A.L.; Silveira, L.R.; Souza, A.O.; Fernandes, A.M.; Eberlin, M.N.; Huang, T.Y.; Zheng, D.; Neufer, P.D.; Cortright, R.N.; Alberici, L.C.
    Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle (2017), J. Physiol., 595, 677-693 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a long-chain fatty acid + CoA Rattus norvegicus
-
 AMP + diphosphate + a long-chain acyl-CoA
-
 ?
ATP + a long-chain fatty acid + CoA Homo sapiens
-
 AMP + diphosphate + an acyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKU0
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myotube
-
 Rattus norvegicus
-
myotube
-
 Homo sapiens
-
skeletal muscle
-
 Rattus norvegicus
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a long-chain fatty acid + CoA
-
 Rattus norvegicus AMP + diphosphate + a long-chain acyl-CoA
-
 ?
ATP + a long-chain fatty acid + CoA
-
 Homo sapiens AMP + diphosphate + an acyl-CoA
-
 ?
ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?
ATP + palmitate + CoA
-
 Homo sapiens AMP + diphosphate + palmitoyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACSL6
-
 Rattus norvegicus
ACSL6
-
 Homo sapiens
long-chain acyl-CoA synthetase 6
-
 Rattus norvegicus
long-chain acyl-CoA synthetase 6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Rattus norvegicus exercise and fasting decrease isoform ACSL6 mRNA down
Homo sapiens exercise and fasting decrease isoform ACSL6 mRNA down
Rattus norvegicus acute lipid ingestion increases the expression of isoform ACSL6 up
Homo sapiens acute lipid ingestion increases the expression of isoform ACSL6 up

General Information

General Information Comment Organism
malfunction isoform ACSL6 genic inhibition in rat primary myotubes decreases lipid accumulation, as well as activates the higher mitochondrial oxidative capacity programme and fatty acid oxidation through the AMP-activated protein kinase/ peroxisome proliferator-activated receptor gamma coactivator 1-alpha pathway Rattus norvegicus
physiological function isoform ACSL6 overexpression in human primary myotubes increases phospholipid species and decreases oxidative metabolism Homo sapiens