Cloned (Comment) | Organism |
---|---|
ACSl5, quantitative real-time PCR expression analysis | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA knockdown of ACSL5 in rat primary hepatocytes | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + octadecanoate + CoA | Rattus norvegicus | - |
AMP + diphosphate + octadecanoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | O88813 | isozyme ACSL5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
additional information | ACSL5 is expressed predominantly in tissues with high rates of triacylglycerol synthesis | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + octadecanoate + CoA | - |
Rattus norvegicus | AMP + diphosphate + octadecanoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACSL5 | - |
Rattus norvegicus |
long-chain acyl-CoA synthetase 5 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | suppression of ACSL5 expression significantly decreases fatty acid-induced lipid droplet formation. ACSL5 knockdown results in decreased oleic acid or acetic acid incorporation into intracellular triacylglycerol, phospholipids, and cholesterol esters without altering fatty acid uptake or lipogenic gene expression. ACSL5 knockdown also decreases hepatic TAG secretion proportionate to the observed decrease in neutral lipid synthesis. ACSL5 knockdown does not alter lipid turnover or mediate the effects of insulin on lipid metabolism, phenotype, detailed overview | Rattus norvegicus |
physiological function | ACSL5 may have an anabolic role in lipid metabolism | Rattus norvegicus |