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Literature summary for 6.2.1.3 extracted from

  • Bu, S.Y.; Mashek, D.G.
    Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways (2010), J. Lipid Res., 51, 3270-3280.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
ACSl5, quantitative real-time PCR expression analysis Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information siRNA knockdown of ACSL5 in rat primary hepatocytes Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + octadecanoate + CoA Rattus norvegicus
-
AMP + diphosphate + octadecanoyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O88813 isozyme ACSL5
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
additional information ACSL5 is expressed predominantly in tissues with high rates of triacylglycerol synthesis Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + octadecanoate + CoA
-
Rattus norvegicus AMP + diphosphate + octadecanoyl-CoA
-
?

Synonyms

Synonyms Comment Organism
ACSL5
-
Rattus norvegicus
long-chain acyl-CoA synthetase 5
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction suppression of ACSL5 expression significantly decreases fatty acid-induced lipid droplet formation. ACSL5 knockdown results in decreased oleic acid or acetic acid incorporation into intracellular triacylglycerol, phospholipids, and cholesterol esters without altering fatty acid uptake or lipogenic gene expression. ACSL5 knockdown also decreases hepatic TAG secretion proportionate to the observed decrease in neutral lipid synthesis. ACSL5 knockdown does not alter lipid turnover or mediate the effects of insulin on lipid metabolism, phenotype, detailed overview Rattus norvegicus
physiological function ACSL5 may have an anabolic role in lipid metabolism Rattus norvegicus