Cloned (Comment) | Organism |
---|---|
expression in COS1 cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Triacsin C | no effect on FATP4 acyl-CoA synthetase activity towards n-tetracosanoic acid, inhibits activity with palmitate with IC50 of 0.03 mM | Mus musculus | |
troglitazone | no effect on FATP4 acyl-CoA synthetase activity towards n-tetracosanoic acid up to 0.05 mM, inhibits activity with palmitate with IC50 of 0.02 mM | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0048 | - |
n-tetracosanoic acid | - |
Mus musculus | |
0.013 | - |
palmitate | - |
Mus musculus | |
0.047 | - |
CoA | - |
Mus musculus | |
1.4 | - |
ATP | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | in vivo the loss of FATP4-mediated very long chain fatty acid uptake and/or esterification may underlie the null phenotype | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.723 | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + n-tetracosanoic acid + CoA | - |
Mus musculus | AMP + diphosphate + n-tetracosanoyl-CoA | - |
? | |
ATP + palmitate + CoA | - |
Mus musculus | AMP + diphosphate + palmitoyl-CoA | - |
? | |
additional information | in vivo the loss of FATP4-mediated very long chain fatty acid uptake and/or esterification may underlie the null phenotype | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FATP4 | bifunctional enzyme, exhibiting both fatty acid transport and acyl-CoA synthetase activities | Mus musculus |
fatty acid transport protein | bifunctional enzyme, exhibiting both fatty acid transport and acyl-CoA synthetase activities | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
substrate: palmitate | Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | about 60% of maximal activity at pH 6.0 and pH 9.0 | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.02 | - |
no effect on FATP4 acyl-CoA synthetase activity towards n-tetracosanoic acid up to 0.05 mM, inhibits activity with palmitate with IC50 of 0.02 mM | Mus musculus | troglitazone | |
0.03 | - |
no effect on FATP4 acyl-CoA synthetase activity towards n-tetracosanoic acid, inhibits activity with palmitate with IC50 of 0.03 mM | Mus musculus | Triacsin C |