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Literature summary for 6.2.1.3 extracted from

  • Jiang, D.W.; Englund, P.T.
    Four Trypanosoma brucei fatty acyl-CoA synthetases: fatty acid specificity of the recombinant proteins (2001), Biochem. J., 358, 757-761.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + arachidonate + CoA
-
Trypanosoma brucei AMP + diphosphate + arachidonoyl-CoA
-
?
ATP + decanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + decanoyl-CoA
-
?
ATP + decenoate + CoA
-
Trypanosoma brucei AMP + diphosphate + decenoyl-CoA
-
?
ATP + docosahexaenoate + CoA
-
Trypanosoma brucei AMP + diphosphate + docosahexaenoyl-CoA
-
?
ATP + docosenoate + CoA
-
Trypanosoma brucei AMP + diphosphate + docosenoyl-CoA
-
?
ATP + dodecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + dodecanoyl-CoA
-
?
ATP + heptadecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + heptadecanoyl-CoA
-
?
ATP + hexadecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + hexadecanoyl-CoA
-
?
ATP + linoleic acid + CoA
-
Trypanosoma brucei AMP + diphosphate + linoleoyl-CoA
-
?
ATP + octadecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + octadecanoyl-CoA
-
?
ATP + oleic acid + CoA
-
Trypanosoma brucei AMP + diphosphate + oleoyl-CoA
-
?
ATP + pentadecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + pentadecanoyl-CoA
-
?
ATP + tetradecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + tetradecanoyl-CoA
-
?
ATP + tridecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + tridecanoyl-CoA
-
?
ATP + undecanoate + CoA
-
Trypanosoma brucei AMP + diphosphate + undecanoyl-CoA
-
?
additional information TbACS1 prefers saturated fatty acids in the range undecanoate to tetradecanoate, TbACS3 and 4, which have 95% sequence identity, have similar specificities favouring fatty acids between tetradecanoate and heptadecanoate. In addition TbACS1, 3 and 4 function well with a variety of unsaturated fatty acids Trypanosoma brucei ?
-
?

Synonyms

Synonyms Comment Organism
TbACS1
-
Trypanosoma brucei
TbACS3
-
Trypanosoma brucei
TbACS4
-
Trypanosoma brucei

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.5
-
tetradecanoate enzyme TbACS1 Trypanosoma brucei
1.1
-
tetradecanoate enzyme TbACS3 Trypanosoma brucei
1.2
-
tetradecanoate enzyme TbACS4 Trypanosoma brucei