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Literature summary for 6.2.1.24 extracted from
- Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes (1995), J. Lipid Res., 36, 986-997.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | the enzyme is synthesized on the cytoplasmic surface and is translocated through the membrane for its alpha-oxidation to pristanic acid in the matrix of peroxisomes | Homo sapiens | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phytanate + CoA | Homo sapiens | phytanoyl-CoA ligase in peroxisomal membrane regulates the oxidation of phytanic acid in peroxisomes by providing phytanoyl-CoA for its transport into peroxisomes | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phytanate + CoA | - |
Homo sapiens | AMP + diphosphate + phytanoyl-CoA | - |
? | |
| ATP + phytanate + CoA | phytanoyl-CoA ligase in peroxisomal membrane regulates the oxidation of phytanic acid in peroxisomes by providing phytanoyl-CoA for its transport into peroxisomes | Homo sapiens | ? | - |
? | |
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