Any feedback?
Literature summary for 6.2.1.23 extracted from
- The microsomal dicarboxylyl-CoA synthetase (1985), Biochem. J., 230, 683-693.
General Stability
| General Stability | Organism |
|---|---|
| freezing and thawing of liver homogenates strongly diminishes its activity within several h | Rattus norvegicus |
| preincubation of fresh liver homogenate in the absence of substrate and cofactors leads to a loss of 75% of its activity within 30 min | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | product inhibition | Rattus norvegicus |  |
| diphosphate | product inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.55 | - |
ATP | - |
Rattus norvegicus | |
| 2.5 | - |
dodecanedioic acid | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the dicarboxylyl-CoA synthetase appears to catalyze an essential step in the degradation of dicarboxylic acids | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| additional information | no activity detected in kidney, jejunum, heart, lung, skeletal muscle, smooth muscle, cerebrum, brain stem | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + decanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + decanedioyl-CoA | - |
? | |
| ATP + dodec-2-enedioic acid + CoA | i.e. traumatic acid, at 40% of the activity relative to dodecanedioic acid | Rattus norvegicus | AMP + diphosphate + dodec-2-enedioyl-CoA | - |
? | |
| ATP + dodecanedioic acid + CoA | highest activity with dodecandioic acid , ATP cannot be replaced by GTP | Rattus norvegicus | AMP + diphosphate + dodecanedioyl-CoA | - |
? | |
| ATP + heptanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + heptanedioyl-CoA | - |
? | |
| ATP + hexadecanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + hexadecanedioyl-CoA | - |
? | |
| ATP + hexanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + hexanedioyl-CoA | - |
? | |
| ATP + octanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + octanedioyl-CoA | - |
? | |
| ATP + pentanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + pentanedioyl-CoA | - |
? | |
| ATP + tetradecanedioic acid + CoA | - |
Rattus norvegicus | AMP + diphosphate + tetradecanedioyl-CoA | - |
? | |
| additional information | the dicarboxylyl-CoA synthetase appears to catalyze an essential step in the degradation of dicarboxylic acids | Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
dodecanedioic acid | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 8.5 | pH 7.4: 40% of maximal activity, pH 8.5: 70% of maximal activity with dodecanedioic acid | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
