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Literature summary for 6.2.1.20 extracted from
- Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli (1976), Proc. Natl. Acad. Sci. USA, 73, 4374-4378.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | stimulates | Escherichia coli |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.013 | - |
stearic acid | - |
Escherichia coli | |
| 0.015 | - |
myristic acid | palmitic acid | Escherichia coli | |
| 0.02 | - |
palmitoleic acid | cis-vaccenic acid, oleic acid, linoleic acid | Escherichia coli | |
| 0.025 | - |
lauric acid | - |
Escherichia coli | |
| 0.1 | - |
Decanoic acid | - |
Escherichia coli | |
| 0.166 | - |
octanoic acid | - |
Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Escherichia coli | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requires high concentrations of both Ca2+ and Mg2+ | Escherichia coli | |
| Mg2+ | requires high concentrations of both Ca2+ and Mg2+ | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + an acid + [acyl-carrier protein] | Escherichia coli | enzyme functions in the incorporation of fatty acids into phospholipid | ? | - |
? | |
| additional information | Escherichia coli | possibly functions in the activation of free fatty acids into a form that can be transferred into phospholipid | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + an acid + [acyl-carrier protein] | enzyme functions in the incorporation of fatty acids into phospholipid | Escherichia coli | ? | - |
? | |
| ATP + cis-vaccenic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + cis-vaccenoyl-[acyl-carrier protein] | - |
? | |
| ATP + decanoic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + decanoyl-[acyl-carrier protein] | - |
? | |
| ATP + lauric acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + lauroyl-[acyl-carrier protein] | - |
? | |
| ATP + linoleic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + linoleoyl-[acyl-carrier protein] | - |
? | |
| ATP + myristic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + myristoyl-[acyl-carrier protein] | - |
? | |
| ATP + octanoic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + octanoyl-[acyl-carrier protein] | - |
? | |
| ATP + oleic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + oleoyl-[acyl-carrier protein] | - |
? | |
| ATP + palmitic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + palmitoyl-[acyl-carrier protein] | - |
? | |
| ATP + palmitoleic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + palmitoleoyl-[acyl-carrier protein] | - |
? | |
| ATP + stearic acid + [acyl-carrier protein] | - |
Escherichia coli | AMP + diphosphate + stearoyl-[acyl-carrier protein] | - |
? | |
| additional information | possibly functions in the activation of free fatty acids into a form that can be transferred into phospholipid | Escherichia coli | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Escherichia coli |
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