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Literature summary for 6.2.1.2 extracted from

  • Kasuya, F.; Igarashi, K.; Fukui, M.
    Characterization of a renal medium chain acyl-CoA synthetase responsible for glycine conjugation in mouse kidney mitochondria (1999), Chem. Biol. Interact., 118, 233-246.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxydodecanoic acid 0.04 mM, 48% inhibition Mus musculus
diflunisal 0.002 mM, 55% inhibition Mus musculus
salicylic acid 0.05 mM, 53% inhibition Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is responsible for glycine conjugation ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.15
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-naphthoic acid + CoA less than 10% of the activity with hexanoic acid Mus musculus AMP + diphosphate + 1-naphthoyl-CoA
-
?
ATP + 1-naphthylacetic acid + CoA about 25% of the activity with hexanoic acid Mus musculus AMP + diphosphate + 1-naphthyl-acetyl-CoA
-
?
ATP + 2-naphthylacetic acid + CoA about 35% of the activity with hexanoic acid Mus musculus AMP + diphosphate + 2-naphthyl-acetyl-CoA
-
?
ATP + 3-aminobenzoate + CoA 29% of the activity with benzoate Mus musculus AMP + diphosphate + 3-aminobenzoyl-CoA
-
?
ATP + 3-chlorobenzoate + CoA 126% of the activity with benzoate Mus musculus AMP + diphosphate + 3-chlorobenzoyl-CoA
-
?
ATP + 3-methoxybenzoate + CoA 54% of the activity with benzoate Mus musculus AMP + diphosphate + 3-methoxybenzoyl-CoA
-
?
ATP + 3-methylbenzoate + CoA 138% of the activity with benzoate Mus musculus AMP + diphosphate + 3-methylbenzoyl-CoA
-
?
ATP + 3-nitrobenzoate + CoA 28% of the activity with benzoate Mus musculus AMP + diphosphate + 3-nitrobenzoyl-CoA
-
?
ATP + 4-aminobenzoate + CoA 19% of the activity with benzoate Mus musculus AMP + diphosphate + 4-aminobenzoyl-CoA
-
?
ATP + 4-chlorobenzoate + CoA 96% of the activity with benzoate Mus musculus AMP + diphosphate + 4-chlorobenzoyl-CoA
-
?
ATP + 4-methoxybenzoate + CoA 43% of the activity with benzoate Mus musculus AMP + diphosphate + 4-methoxybenzoyl-CoA
-
?
ATP + 4-methylbenzoate + CoA 114% of the activity with benzoate Mus musculus AMP + diphosphate + 4-methylbenzoyl-CoA
-
?
ATP + 4-nitrobenzoate + CoA 29% of the activity with benzoate Mus musculus AMP + diphosphate + 4-nitrobenzoyl-CoA
-
?
ATP + benzoate + CoA about 30% of the activity with hexanoic acid Mus musculus AMP + diphosphate + benzoyl-CoA
-
?
ATP + hexanoate + CoA
-
Mus musculus AMP + diphosphate + hexanoyl-CoA
-
?
ATP + indomethacin + CoA less than 5% of the activity with hexanoic acid Mus musculus AMP + diphosphate + ?
-
?
ATP + octanoate + CoA about 50% of the activity with hexanoic acid Mus musculus AMP + diphosphate + octanoyl-CoA
-
?
ATP + tranexamic acid + CoA less than 10% of the activity with hexanoic acid Mus musculus AMP + diphosphate + tranexoyl-CoA
-
?
ATP + valproic acid + CoA less than 10% of the activity with hexanoic acid Mus musculus AMP + diphosphate + valproyl-CoA
-
?
additional information the enzyme is responsible for glycine conjugation Mus musculus ?
-
?