Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.2.1.2 extracted from

  • Kasuya, F.; Yamaoka, Y.; Igarashi, K.; Fukui, M.
    Molecular specificity of a medium chain acyl-CoA synthetase for substrates and inhibitors: conformational analysis (1998), Biochem. Pharmacol., 55, 1769-1775.
    View publication on PubMed
Search for more literature for 6.2.1.2

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxydodecanoic acid
-
 Bos taurus
2-hydroxyphenylacetic acid
-
 Bos taurus
diflunisal competitive Bos taurus
Nalidixic acid competitive Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-anthracenecarboxylic acid + CoA 2% of the activity with hexanoic acid Bos taurus AMP + diphosphate + anthracene-1-carboxyl-CoA
-
 ?
ATP + 1-naphthoic acid + CoA 3% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 1-naphthoyl-CoA
-
 ?
ATP + 1-naphthylacetic acid + CoA 18% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 1-naphthyl-acetyl-CoA
-
 ?
ATP + 2-anthracenecarboxylic acid + CoA 16% of the activity with hexanoic acid Bos taurus AMP + diphosphate + anthracene-2-carboxyl-CoA
-
 ?
ATP + 2-naphthylacetic acid + CoA 21% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 2-naphthyl-acetyl-CoA
-
 ?
ATP + 3-aminobenzoate + CoA 5% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 3-aminobenzoyl-CoA
-
 ?
ATP + 3-chlorobenzoate + CoA 12% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 3-chlorobenzoyl-CoA
-
 ?
ATP + 3-methoxybenzoate + CoA 48% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 3-methoxybenzoyl-CoA
-
 ?
ATP + 3-methylbenzoate + CoA 23% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 3-methylbenzoyl-CoA
-
 ?
ATP + 4-aminobenzoate + CoA 3% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 4-aminobenzoyl-CoA
-
 ?
ATP + 4-chlorobenzoate + CoA 17% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 4-chlorobenzoyl-CoA
-
 ?
ATP + 4-heptylbenzoate + CoA 66% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 4-heptylbenzoyl-CoA
-
 ?
ATP + 4-methoxybenzoate + CoA 47% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 4-methoxybenzoyl-CoA
-
 ?
ATP + 4-methylbenzoate + CoA 59% of the activity with hexanoic acid Bos taurus AMP + diphosphate + 4-methylbenzoyl-CoA
-
 ?
ATP + benzoate + CoA 19% of the activity with hexanoic acid Bos taurus AMP + diphosphate + benzoyl-CoA
-
 ?
ATP + cyclohexanoic acid + CoA 41% of the activity with hexanoic acid Bos taurus AMP + diphosphate + cyclohexanoyl-CoA
-
 ?
ATP + dodecanoate + CoA 39% of the activity with hexanoic acid Bos taurus AMP + diphosphate + dodecanoyl-CoA
-
 ?
ATP + hexanoate + CoA
-
 Bos taurus AMP + diphosphate + hexanoyl-CoA
-
 ?
ATP + indomethacin + CoA 6% of the activity with hexanoic acid Bos taurus AMP + diphosphate + ?
-
 ?
ATP + tranexamic acid + CoA 7% of the activity with hexanoic acid Bos taurus AMP + diphosphate + tranexoyl-CoA
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
 diflunisal pH 8.5 Bos taurus
0.0044
-
 2-hydroxydodecanoic acid pH 8.5 Bos taurus
0.0123
-
 Nalidixic acid pH 8.5 Bos taurus
0.37
-
 2-hydroxyphenylacetic acid pH 8.5 Bos taurus