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Literature summary for 6.2.1.17 extracted from

  • Horswill, A.R.; Escalante-Semerena, J.C.
    The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase (1999), Microbiology, 145, 1381-1388.
No PubMed abstract available
Search for more literature for 6.2.1.17

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in strain JE4184 Salmonella enterica subsp. enterica serovar Typhimurium

Localization

Localization Comment Organism GeneOntology No. Textmining
inclusion body small quantity of enzyme Salmonella enterica subsp. enterica serovar Typhimurium 16234
-
soluble
-
 Salmonella enterica subsp. enterica serovar Typhimurium
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + propanoate + CoA Salmonella enterica subsp. enterica serovar Typhimurium required for propionate catabolism AMP + diphosphate + propanoyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.3
-
 pH 7.5, 37°C, with acetate as substrate Salmonella enterica subsp. enterica serovar Typhimurium
0.63
-
 pH 7.5, 37°C, with propanoate as substrate Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA 48% of the activity relative to propanoate Salmonella enterica subsp. enterica serovar Typhimurium AMP + diphosphate + acetyl-CoA
-
 ?
ATP + propanoate + CoA
-
 Salmonella enterica subsp. enterica serovar Typhimurium AMP + diphosphate + propanoyl-CoA
-
 ?
ATP + propanoate + CoA required for propionate catabolism Salmonella enterica subsp. enterica serovar Typhimurium AMP + diphosphate + propanoyl-CoA
-
 ?
additional information no activity with butyrate, GTP, ITP, CTP and TTP Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?