Cloned (Comment) | Organism |
---|---|
functional overexpression of ACSL4 variant 1 in smooth muscle cells using a retroviral vector, semiquantitative and quantitative real-time PCR expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of ACSL4 by stable expression of ACSL4 siRNAs in immortalized human primary aortic smooth muscle cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + arachidonate + CoA | Homo sapiens | arachidonic acid is a preferred substrate for ACSL4 variant 1 in intact human smooth muscle cells | AMP + diphosphate + arachidonoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60488 | ACSL4 variant 1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle cell | aortic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + arachidonate + CoA | preferred substrate | Homo sapiens | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
ATP + arachidonate + CoA | arachidonic acid is a preferred substrate for ACSL4 variant 1 in intact human smooth muscle cells | Homo sapiens | AMP + diphosphate + arachidonoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACSL4 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |