BRENDA - Enzyme Database
show all sequences of 6.2.1.13

In Salmonella enterica, the sirtuin-dependent protein acylation/deacylation system (SDPADS) maintains energy homeostasis during growth on low concentrations of acetate

Chan, C.; Garrity, J.; Crosby, H.; Escalante-Semerena, J.; Mol. Microbiol. 80, 168-183 (2011)

Data extracted from this reference:

Engineering
Protein Variants
Commentary
Organism
G266S
the Acs mutant does not cause growth arrest in contrast to the wild-type enzyme
Salmonella enterica
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + acetate + CoA
Salmonella enterica
-
ADP + phosphate + acetyl-CoA
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Salmonella enterica
-
gene acs
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + acetate + CoA
-
716267
Salmonella enterica
ADP + phosphate + acetyl-CoA
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
acetyl-coenzyme A synthetase
-
Salmonella enterica
ACS
-
Salmonella enterica
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Salmonella enterica
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Salmonella enterica
Engineering (protein specific)
Protein Variants
Commentary
Organism
G266S
the Acs mutant does not cause growth arrest in contrast to the wild-type enzyme
Salmonella enterica
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + acetate + CoA
Salmonella enterica
-
ADP + phosphate + acetyl-CoA
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + acetate + CoA
-
716267
Salmonella enterica
ADP + phosphate + acetyl-CoA
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
growth arrest is caused by elevated Acs, EC 6.2.1.1, activity, while overproduction of ADP-forming Ac-CoA synthesizing systems do not affect the growth behaviour of acetylation-deficient or acetylation-proficient strains
Salmonella enterica
General Information (protein specific)
General Information
Commentary
Organism
physiological function
growth arrest is caused by elevated Acs, EC 6.2.1.1, activity, while overproduction of ADP-forming Ac-CoA synthesizing systems do not affect the growth behaviour of acetylation-deficient or acetylation-proficient strains
Salmonella enterica
Other publictions for EC 6.2.1.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744911
Jones
Investigating the mechanism o ...
Entamoeba histolytica
FEBS Lett.
591
603-612
2017
-
-
1
-
14
-
-
46
-
1
-
4
-
2
-
-
1
1
-
-
-
-
5
1
5
-
-
-
48
-
-
-
2
-
-
-
-
-
1
3
-
17
-
-
-
-
46
-
1
-
4
-
-
-
1
-
-
-
-
5
1
-
-
-
48
-
-
-
-
-
2
2
-
48
48
744414
Pineda
Roles of acetyl-CoA synthetas ...
Entamoeba histolytica
Biochim. Biophys. Acta
1860
1163-1172
2016
-
-
1
-
1
-
-
13
-
1
-
2
-
2
-
-
1
-
-
1
-
1
3
1
3
1
-
-
8
3
1
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
13
-
1
-
2
-
-
-
1
-
1
-
1
3
1
1
-
-
8
3
1
-
-
-
2
2
-
12
12
746438
Barnhart
Potential role of acetyl-CoA ...
Methanosarcina acetivorans
Sci. Rep.
5
12498
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744820
Jones
Biochemical and kinetic chara ...
Entamoeba histolytica
Eukaryot. Cell
13
1530-1537
2014
-
-
1
-
-
-
9
14
-
3
1
2
-
2
-
-
1
-
-
-
-
-
26
1
3
1
1
-
14
-
-
-
4
-
-
3
-
-
1
4
-
-
-
3
9
-
14
-
3
1
2
-
-
-
1
-
-
-
-
26
1
1
1
-
14
-
-
-
-
-
-
-
-
14
14
745215
Awano
Characterization of two membe ...
Thermococcus kodakarensis
J. Bacteriol.
196
140-147
2014
-
-
1
-
-
-
-
6
-
-
-
1
-
6
-
-
1
-
-
-
-
-
8
-
4
-
-
-
6
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
6
-
-
-
1
-
-
-
1
-
-
-
-
8
-
-
-
-
6
-
-
-
-
-
-
-
-
6
6
727557
Schmidt
Acetate formation in the photo ...
Chloroflexus aurantiacus, Chloroflexus aurantiacus J-10-fl
FEMS Microbiol. Lett.
349
171-179
2013
-
-
1
-
-
-
-
6
-
1
4
4
-
8
-
-
1
-
-
-
-
-
17
1
3
1
-
-
-
1
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
6
-
1
4
4
-
-
-
1
-
-
-
-
17
1
1
-
-
-
1
1
-
-
1
-
-
1
-
-
716267
Chan
In Salmonella enterica, the si ...
Salmonella enterica
Mol. Microbiol.
80
168-183
2011
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
693061
Braesen
Reaction mechanism and structu ...
Pyrococcus furiosus
J. Biol. Chem.
283
15409-15418
2008
-
-
1
-
7
-
-
20
-
1
5
2
-
2
-
1
1
1
-
-
-
-
4
3
4
2
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
7
-
-
-
-
23
-
1
5
2
-
-
1
2
-
-
-
-
4
3
3
-
-
-
2
-
-
-
-
-
-
-
-
-
674281
Hu
Citric acid cycle in the hyper ...
Pyrobaculum islandicum
J. Bacteriol.
188
4350-4355
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660615
Lehtioe
Unusual twinning in an acetyl ...
Pyrococcus furiosus
Acta Crystallogr. Sect. D
D61
350-354
2005
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663376
De Cima
An acetyl-CoA synthetase not e ...
Phycomyces blakesleeanus
Res. Microbiol.
156
663-669
2005
-
-
-
-
-
-
-
4
-
4
2
2
-
1
-
-
1
-
-
1
-
-
4
1
2
2
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
4
2
2
-
-
-
1
-
1
-
-
4
1
2
2
-
-
1
-
-
-
-
-
-
-
-
-
660834
Bräsen
Unusual ADP-forming acetyl-coe ...
Haloarcula marismortui, Pyrobaculum aerophilum
Arch. Microbiol.
182
277-287
2004
-
-
2
-
-
1
2
9
-
1
2
2
-
2
-
-
2
-
-
-
1
-
10
1
-
2
1
3
-
2
2
-
-
-
-
-
-
-
2
-
-
-
1
-
2
-
9
-
1
2
2
-
-
-
2
-
-
1
-
10
1
2
1
3
-
2
2
-
-
-
-
-
-
-
-
661791
Bräsen
Regulation of acetate and acet ...
Haloarcula marismortui
FEMS Microbiol. Lett.
241
21-26
2004
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649507
Brasen
Mechanisms of acetate formatio ...
Halococcus saccharolyticus, Haloferax volcanii, Halorubrum saccharovorum
Arch. Microbiol.
175
360-368
2001
-
-
-
-
-
1
-
3
3
1
3
3
-
7
-
-
3
-
-
2
5
-
5
-
6
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
3
3
1
3
3
-
-
-
3
-
2
5
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662774
Kretzschmar
The Pseudomonas aeruginosa acs ...
Pseudomonas aeruginosa
Microbiology
147
2671-2677
2001
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721449
Labes
Sugar utilization in the hyper ...
Archaeoglobus fulgidus, Archaeoglobus fulgidus 7324
Arch. Microbiol.
176
329-338
2001
-
-
-
-
-
-
-
3
-
-
-
1
-
9
-
-
-
-
-
2
2
-
3
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
2
2
-
3
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
651402
Sanchez
Cloning and sequencing of an a ...
Giardia intestinalis, Giardia intestinalis WB / CC 30957
Gene
233
225-231
1999
-
-
1
-
-
-
-
3
-
-
1
2
-
9
-
-
-
-
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
3
-
-
1
2
-
-
-
-
-
-
-
-
6
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
651644
Musfeldt
Acetyl coenzyme A synthetase ( ...
Giardia intestinalis, Pyrococcus furiosus
J. Bacteriol.
181
5885-5888
1999
-
-
2
-
-
-
-
9
2
1
3
2
-
3
-
-
2
-
1
1
-
-
6
2
1
1
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
9
2
1
3
2
-
-
-
2
1
1
-
-
6
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
625
Glasemacher
Purification and properties of ...
Pyrococcus furiosus
Eur. J. Biochem.
244
561-567
1997
-
-
-
-
-
2
-
6
-
4
4
1
-
3
-
-
1
-
-
-
1
2
10
1
-
1
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
6
-
4
4
1
-
-
-
1
-
-
1
2
10
1
1
-
2
-
1
1
-
-
-
-
-
-
-
-
624
Sanchez
Purification and characterizat ...
Giardia intestinalis
FEBS Lett.
378
240-244
1996
-
-
-
-
-
-
-
3
-
3
-
1
-
3
-
-
1
-
-
-
1
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
1
-
-
-
1
-
-
1
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
626
Mai
Purification and characterizat ...
Pyrococcus furiosus
J. Bacteriol.
178
5897-5903
1996
-
-
-
-
-
-
-
16
-
1
3
-
-
1
1
-
1
-
-
-
2
-
8
1
-
1
1
1
22
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
1
3
-
-
1
-
1
-
-
2
-
8
1
1
1
1
22
1
2
-
-
-
-
-
-
-
-
744177
Schäfer
-
Maltose fermentation to aceta ...
Pyrococcus furiosus
Arch. Microbiol.
158
188-202
1992
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
623
Schäfer
-
Pyruvate metabolism of the hyp ...
Pyrococcus furiosus
Arch. Microbiol.
155
366-377
1991
-
-
-
-
-
-
-
6
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
627
Reeves
An energy-conserving pyruvate- ...
Entamoeba histolytica
J. Biol. Chem.
252
726-731
1977
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-