Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.2.1.12 extracted from

  • Li, Y.; Kim, J.I.; Pysh, L.; Chapple, C.
    Four isoforms of Arabidopsis 4-coumarate CoA ligase have overlapping yet distinct roles in phenylpropanoid metabolism (2015), Plant Physiol., 169, 2409-2421 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.12

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 4-coumarate + CoA Arabidopsis thaliana
-
 AMP + diphosphate + 4-coumaroyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q42524
-
-
Arabidopsis thaliana Q9LU36
-
-
Arabidopsis thaliana Q9S725
-
-
Arabidopsis thaliana Q9S777
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cotyledon
-
 Arabidopsis thaliana
-
interfascicular region
-
 Arabidopsis thaliana
-
leaf
-
 Arabidopsis thaliana
-
petal
-
 Arabidopsis thaliana
-
phloem
-
 Arabidopsis thaliana
-
pith
-
 Arabidopsis thaliana
-
root
-
 Arabidopsis thaliana
-
seedling
-
 Arabidopsis thaliana
-
sepal
-
 Arabidopsis thaliana
-
stem cortex
-
 Arabidopsis thaliana
-
stigma
-
 Arabidopsis thaliana
-
xylem
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 4-coumarate + CoA
-
 Arabidopsis thaliana AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
ATP + caffeate + CoA
-
 Arabidopsis thaliana AMP + diphosphate + caffeoyl-CoA
-
 ?
ATP + sinapoylmalate + CoA substrate for isoform 4CL1 Arabidopsis thaliana AMP + diphosphate + sinapoylmaloyl-CoA
-
 ?
ATP + sinapoylmalate + CoA substrate for isoform 4CL3 Arabidopsis thaliana AMP + diphosphate + sinapoylmaloyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
4-coumarate:CoA ligase
-
 Arabidopsis thaliana
4CL1 isoform Arabidopsis thaliana
4CL2 isoform Arabidopsis thaliana
4CL3 isoform Arabidopsis thaliana
4CL4 isoform Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction loss of isoform 4CL1 leads to reduction in lignin content but no growth defect Arabidopsis thaliana
metabolism isoform 4CL3 plays an important role in flavonoid biosynthesis Arabidopsis thaliana
physiological function isoform 4CL1 is required for wild type levels of lignin biosynthesis Arabidopsis thaliana