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Literature summary for 6.2.1.1 extracted from

  • Vysochan, A.; Sengupta, A.; Weljie, A.M.; Alwine, J.C.; Yu, Y.
    ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection (2017), Proc. Natl. Acad. Sci. USA, 114, E1528-E1535 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Homo sapiens
-
 AMP + diphosphate + acetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NR19
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
fibroblast cell line the CRISPR/Cas9 system is used to create an ACLY-KO human fibroblast (HF) cell line called C9 Homo sapiens
-
foreskin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
-
 Homo sapiens AMP + diphosphate + acetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
acetyl-CoA synthetase short-chain family member 2
-
 Homo sapiens
ACSS2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection and can compensate for the loss of ATP-citrate lyase Homo sapiens