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Literature summary for 6.2.1.1 extracted from

  • Ding, J.; Holzwarth, G.; Penner, M.H.; Patton-Vogt, J.; Bakalinsky, A.T.
    Overexpression of acetyl-CoA synthetase in Saccharomyces cerevisiae increases acetic acid tolerance (2015), FEMS Microbiol. Lett., 362, 1-7 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Saccharomyces cerevisiae
-
 AMP + diphosphate + acetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P52910
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
-
 Saccharomyces cerevisiae AMP + diphosphate + acetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
Acetyl-CoA synthetase
-
 Saccharomyces cerevisiae
acetyl-coenzyme A synthetase
-
 Saccharomyces cerevisiae
ACS2
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function enzyme overexpression results in higher resistance to acetic acid as measured by an increased growth rate and shorter lag phase relative to a wild type strain, suggesting that enzyme-mediated consumption of acetic acid during fermentation contributes to acetic acid detoxification Saccharomyces cerevisiae