Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | AceCS1 | Mus musculus | 5829 | - |
mitochondrion | matrix, AceCS2 | Mus musculus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
71000 | - |
x * 71000, AceCS2, SDS-PAGE | Mus musculus |
74309 | - |
x * 74309, calculation from nucleotide sequence | Bos taurus |
74662 | - |
x * 74662, AceCS2, calculation from nucleotide sequence | Mus musculus |
78000 | - |
x * 78000, AceCS1, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dATP + acetate + CoA | Mus musculus | AceCS2 plays a role in the production of energy under ketogenic conditions, such as starvation and diabetes. Acetyl-CoAs produced by AceCS2 are utilized mainly for oxidation | dAMP + diphosphate + acetyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q9BEA3 | - |
- |
Mus musculus | - |
- |
- |
Mus musculus | Q99NB1 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the putative mitochondrial targeting signal is cleaved during the transportation of the enzyme into the mitochondria matrix | Mus musculus |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | marked induction of AceCS1 mRNA and protein during differentiation of 3T3-L1 cells, neither AceCS2 mRNA nor protein is detected in undifferentiated or differentiated 3T3-L1 cells | Mus musculus | - |
brain | AceCS2, low activity | Mus musculus | - |
heart | AceCS2, high activity | Mus musculus | - |
kidney | AceCS2, high activity | Mus musculus | - |
liver | AceCS1, no AceCS2 activity | Mus musculus | - |
lung | AceCS2, high activity | Mus musculus | - |
additional information | no AceCS2 activity is detected in liver. Marked induction of AceCS1 mRNA and protein during differentiation of 3T3-L1 cells, neither AceCS2 mRNA nor protein is detected in undifferentiated or differentiated 3T3-L1 cells | Mus musculus | - |
skeletal muscle | AceCS2, high activity | Mus musculus | - |
spleen | AceCS2, high activity | Mus musculus | - |
testis | AceCS2, high activity | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
11.9 | - |
AceCS2 | Mus musculus |
26.8 | - |
AceCS1 | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dATP + acetate + CoA | - |
Mus musculus | dAMP + diphosphate + acetyl-CoA | - |
? | |
dATP + acetate + CoA | AceCS2 plays a role in the production of energy under ketogenic conditions, such as starvation and diabetes. Acetyl-CoAs produced by AceCS2 are utilized mainly for oxidation | Mus musculus | dAMP + diphosphate + acetyl-CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 71000, AceCS2, SDS-PAGE | Mus musculus |
? | x * 74309, calculation from nucleotide sequence | Bos taurus |
? | x * 74662, AceCS2, calculation from nucleotide sequence | Mus musculus |
? | x * 78000, AceCS1, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
AceCS1 | liver enzyme, 45.8% amino acid identity between AceCS1 and AceCS2 | Mus musculus |
AceCS2 | heart enzyme, 45.8% amino acid identity between AceCS1 and AceCS2 | Mus musculus |