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Literature summary for 6.1.2.1 extracted from

  • Van Der Aart, L.; Lemmens, N.; Van Wamel, W.; Van Wezel, G.
    Substrate inhibition of VanA by D-alanine reduces vancomycin resistance in a VanX-dependent manner (2016), Antimicrob. Agents Chemother., 60, 4930-4939 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
D-alanine substrate inhibition Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + (R)-lactate + ATP Streptomyces coelicolor
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
D-alanine + (R)-lactate + ATP Streptomyces coelicolor ATCC BAA-471
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
D-alanine + (R)-lactate + ATP Streptomyces coelicolor M145
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
-
-
-
Streptomyces coelicolor M145
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + (R)-lactate + ATP
-
 Streptomyces coelicolor D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
D-alanine + (R)-lactate + ATP
-
 Streptomyces coelicolor ATCC BAA-471 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
D-alanine + (R)-lactate + ATP
-
 Streptomyces coelicolor M145 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
D-Ala-D-Lac ligase
-
 Streptomyces coelicolor
D-alanyl-D-lactate ligase
-
 Streptomyces coelicolor
VanA
-
 Streptomyces coelicolor

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Streptomyces coelicolor