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Literature summary for 6.1.2.1 extracted from
- VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin (2009), Antimicrob. Agents Chemother., 53, 1974-1982.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecium | - |
BM 4660 | - |
| Enterococcus faecium BM 4660 | - |
BM 4660 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| VanB | - |
Enterococcus faecium |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in the presence of vancomycin, production of the VanB D-Ala:D-Lac ligase is induced, which overcomes the defect in the synthesis of peptidoglycan precursors ending in D-AlaD-Ala due to a lack of functional Ddl D-Ala-D-Ala ligase. Vancomycin-dependent strain BM4660 synthesizes mainly UDP-MurNAc-pentadepsipeptide, 44%, whereas large amounts of UDP-MurNActripeptide, 39%, and small amounts of pentapeptide, 12%, and tetrapeptide, 5%, are present. The presence of tripeptide in large quantity suggests that the VanB ligase may not be sufficiently active to synthesize D-AlaD-Lac as rapidly as tripeptide is produced | Enterococcus faecium |
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