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Literature summary for 6.1.2.1 extracted from
- Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil (2000), Antimicrob. Agents Chemother., 44, 3444-3446.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecium | - |
10/96A | - |
| Enterococcus faecium 10/96A | - |
10/96A | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| VanD4 | - |
Enterococcus faecium |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Enterococcus faecium 10/96A from Brazil is resistant to vancomycin with a minimum inhibitory concentration MIC of 0.256 mg/ml. Cytoplasmic peptidoglycan precursors from cells of strain 10/96A grown in the presence or absence of 0.004 mg of vancomycin/ml contain in both cases 95% UDP-MurNAc-pentadepsipeptide, 3% UDPMurNAc-pentapeptide, and 2% UDP-MurNAc-tetrapeptide, supporting the role of VanD4 as a D-Ala-D-Lac ligase and indicating that glycopeptide resistance is expressed constitutively | Enterococcus faecium |
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