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Literature summary for 6.1.1.9 extracted from
- The mechanism of inhibition of valyl-tRNA synthetase by S-adenosylhomocysteine (1982), Biochim. Biophys. Acta, 709, 325-331.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosylhomocysteine | competitive with respect to ATP and valine in the ATP-diphosphate exchange reaction, noncompetitive with respect to ATP and valine and uncompetitive with respect ro tRNA in the tRNA aminoacylation | Lupinus luteus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lupinus luteus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Lupinus luteus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-valine + tRNAVal | - |
Lupinus luteus | AMP + diphosphate + L-valyl-tRNAVal | - |
? | |
| additional information | valine-dependent ATP-diphosphate exchange: valine + ATP + enzyme /Val-AMP-enzyme + diphosphate | Lupinus luteus | ? | - |
? | |
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Release 2023.1 (January 2023)
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