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Literature summary for 6.1.1.6 extracted from

  • Dewan, V.; Wei, M.; Kleiman, L.; Musier-Forsyth, K.
    Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1 (2012), J. Biol. Chem., 287, 41955-41962.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
F244A the mutant shows 90% aminoacylation activity compared to the wild type enzyme Homo sapiens
F244A/I245A the mutant shows 90% aminoacylation activity compared to the wild type enzyme Homo sapiens
I245A the mutant shows wild type aminoacylation activity Homo sapiens
I246D the mutant shows 60% aminoacylation activity compared to the wild type enzyme Homo sapiens
I246D/R247A the mutant shows 20% aminoacylation activity compared to the wild type enzyme Homo sapiens
I250D the mutant shows 40% aminoacylation activity compared to the wild type enzyme Homo sapiens
I250D/I251D the mutant shows 20% aminoacylation activity compared to the wild type enzyme Homo sapiens
I251D the mutant shows 40% aminoacylation activity compared to the wild type enzyme Homo sapiens
I254D the mutant shows 40% aminoacylation activity compared to the wild type enzyme Homo sapiens
I254D/R255A the mutant shows 30% aminoacylation activity compared to the wild type enzyme Homo sapiens
K249A the mutant shows 90% aminoacylation activity compared to the wild type enzyme Homo sapiens
R247A the mutant shows 30% aminoacylation activity compared to the wild type enzyme Homo sapiens
R255A the mutant shows 40% aminoacylation activity compared to the wild type enzyme Homo sapiens
S248D the mutant shows wild type aminoacylation activity Homo sapiens
S248D/K249A the mutant shows wild type aminoacylation activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Homo sapiens
-
 AMP + diphosphate + L-lysyl-tRNALys
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
-
 Homo sapiens AMP + diphosphate + L-lysyl-tRNALys
-
 ?

Synonyms

Synonyms Comment Organism
LysRS
-
 Homo sapiens
Lysyl-tRNA synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens