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Literature summary for 6.1.1.6 extracted from

  • Sissler, M.; Helm, M.; Frugier, M.; Giege, R.; Florentz, C.
    Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants (2004), RNA, 10, 841-853.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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Homo sapiens 5829
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys pathology-related human mitochondrial tRNA(Lys) variants as substrates. G8313A or G8328A mutations in tRNA(Lys) lead to drastic decreases (500fold to 7000fold) in lysylation efficiency. Mutations in tRNA(Lys) that have no effect on aminoacylation: A8296G, U8316G, G8342A, U8356C, U8362G, G8363A Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
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