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Literature summary for 6.1.1.6 extracted from

  • Park, S.G.; Kim, H.J.; Min, Y.H.; Choi, E.C.; Shin, Y.K.; Park, B.J.; Lee, S.W.; Kim, S.
    Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response (2005), Proc. Natl. Acad. Sci. USA, 102, 6356-6361.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.6

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Homo sapiens the enzyme is secreted to trigger proinflammatory response. TNF-alpha induces secretion of lysyl-tRNA synthetase. The secreted enzyme binds to macrophages and peripheral blood mononuclear cell to enhance the TNF-alpha production and their migration. The mitogen-activated protein kinases, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and inhibitory protein Galphai are involved in the signal transduction triggered by lysyl-tRNA synthetase. Lysyl-tRNA synthetase may work as a signaling molecule, inducing immune response through the activation of monocyte/macrophages AMP + L-lysyl-tRNALys + diphosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
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 Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
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 ?
ATP + L-lysine + tRNALys the enzyme is secreted to trigger proinflammatory response. TNF-alpha induces secretion of lysyl-tRNA synthetase. The secreted enzyme binds to macrophages and peripheral blood mononuclear cell to enhance the TNF-alpha production and their migration. The mitogen-activated protein kinases, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and inhibitory protein Galphai are involved in the signal transduction triggered by lysyl-tRNA synthetase. Lysyl-tRNA synthetase may work as a signaling molecule, inducing immune response through the activation of monocyte/macrophages Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
 ?