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Literature summary for 6.1.1.6 extracted from

  • Guo, F.; Gabor, J.; Cen, S.; Hu, K.; Mouland, A.J.; Kleiman, L.
    Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase (2005), J. Biol. Chem., 280, 26018-26023.
    View publication on PubMed
Search for more literature for 6.1.1.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Homo sapiens during early assembly of human immunodeficiency virus type 1, an assembly complex is formed, the components of which include genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase. Directly increasing or decreasing cellular expression of LysRS results in corresponding changes in viral infectivity and in the viral concentrations of LysRS, tRNALys, and reverse transcriptase. Overexpression of LysRS in the cell reduces viral protease activity AMP + L-lysyl-tRNALys + diphosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell infected with HIV-1, during early assembly of human immunodeficiency virus type 1, an assembly complex is formed, the components of which include genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase. Directly increasing or decreasing cellular expression of LysRS results in corresponding changes in viral infectivity and in the viral concentrations of LysRS, tRNALys, and reverse transcriptase. Overexpression of LysRS in the cell reduces viral protease activity Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
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 Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
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 ?
ATP + L-lysine + tRNALys during early assembly of human immunodeficiency virus type 1, an assembly complex is formed, the components of which include genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase. Directly increasing or decreasing cellular expression of LysRS results in corresponding changes in viral infectivity and in the viral concentrations of LysRS, tRNALys, and reverse transcriptase. Overexpression of LysRS in the cell reduces viral protease activity Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
Lysyl-tRNA synthetase
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 Homo sapiens