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Literature summary for 6.1.1.6 extracted from

  • Javanbakht, H.; Halwani, R.; Cen, S.; Saadatmand, J.; Musier-Forsyth, K.; Gottlinger, H.; Kleiman, L.
    The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly (2003), J. Biol. Chem., 278, 27644-27651.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information specific binding to HIV Gag protein, thereby signaling and mediation of selective recognition and packaging of tRNALys isoacceptors as well as the enzyme itself into HIV particles, the Gag protein alone is sufficient for the incorporation, determination and mapping of interaction regions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + lysine + tRNALys Homo sapiens
-
AMP + L-lysyl-tRNALys + diphosphate
-
?
additional information Homo sapiens the enzyme signals and mediates the selective recognition and packaging of tRNALys isoacceptors into HIV particles, the human enzyme is selectively packaged into virions of the human immunodeficiency virus during virus assembly, along with and independent of its cognate tRNALys isoacceptors, packaging is mediated by the viral protein Gag, which alone is sufficient for the incorporation, determination of interaction regions ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme is N-terminally cleaved during incorporation into HIV particles Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + lysine + tRNALys
-
Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
?
additional information the enzyme signals and mediates the selective recognition and packaging of tRNALys isoacceptors into HIV particles, the human enzyme is selectively packaged into virions of the human immunodeficiency virus during virus assembly, along with and independent of its cognate tRNALys isoacceptors, packaging is mediated by the viral protein Gag, which alone is sufficient for the incorporation, determination of interaction regions Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
L-Lysine-transfer RNA ligase
-
Homo sapiens
Lysine translase
-
Homo sapiens
Lysine--tRNA ligase
-
Homo sapiens
Lysine-tRNA synthetase
-
Homo sapiens
LysRS
-
Homo sapiens
Lysyl-transfer ribonucleate synthetase
-
Homo sapiens
Lysyl-transfer RNA synthetase
-
Homo sapiens
Lysyl-tRNA synthetase
-
Homo sapiens
Synthetase, lysyl-transfer ribonucleate
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens