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Literature summary for 6.1.1.5 extracted from

  • Rettig, J.; Wang, Y.; Schneider, A.; Ochsenreiter, T.
    Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicing (2012), Nucleic Acids Res., 40, 1299-1306.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol short spliced variant Trypanosoma brucei 5829
-
mitochondrion large isoform Trypanosoma brucei 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
123500
-
x * 123500, short spliced variant, calculated from amino acid sequence Trypanosoma brucei
125900
-
x * 125900, mitochondrial isoform, calculated from amino acid sequence Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-isoleucine + tRNAIle Trypanosoma brucei
-
AMP + diphosphate + L-isoleucyl-tRNAIle
-
?
ATP + L-isoleucine + tRNAIle Trypanosoma brucei 29-13
-
AMP + diphosphate + L-isoleucyl-tRNAIle
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-
Trypanosoma brucei 29-13
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-isoleucine + tRNAIle
-
Trypanosoma brucei AMP + diphosphate + L-isoleucyl-tRNAIle
-
?
ATP + L-isoleucine + tRNAIle
-
Trypanosoma brucei 29-13 AMP + diphosphate + L-isoleucyl-tRNAIle
-
?

Subunits

Subunits Comment Organism
? x * 123500, short spliced variant, calculated from amino acid sequence Trypanosoma brucei
? x * 125900, mitochondrial isoform, calculated from amino acid sequence Trypanosoma brucei

Synonyms

Synonyms Comment Organism
IleRS
-
Trypanosoma brucei
Isoleucyl-tRNA synthetase
-
Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
ATP
-
Trypanosoma brucei

General Information

General Information Comment Organism
physiological function the single trypanosomal IleRS gene is essential for normal growth and for charging of cytosolic and mitochondrial tRNAIle Trypanosoma brucei