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Literature summary for 6.1.1.5 extracted from

  • Shimizu, T.; Usui, T.; Fujikura, M.; Kawatani, M.; Satoh, T.; Machida, K.; Kanoh, N.; Woo, J.T.; Osada, H.; Sodeoka, M.
    Synthesis and biological activities of reveromycin A and spirofungin A derivatives (2008), Bioorg. Med. Chem. Lett., 18, 3756-3760.
    View publication on PubMed
Search for more literature for 6.1.1.5

Inhibitors

Inhibitors Comment Organism Structure
(2E,4E)-5-[(2S,3R,6S,8R,9S)-3-butyl-3-[(3-carboxypropanoyl)oxy]-8-(2-hydroxyethyl)-9-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-3-methylpenta-2,4-dienoic acid IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): not determined Homo sapiens
(2E,4E)-5-[(2S,3R,6S,8R,9S)-3-butyl-3-[(3-carboxypropanoyl)oxy]-8-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-3-methylpenta-2,4-dienoic acid IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): not determined Homo sapiens
(2E,4E)-5-[(2S,3R,6S,8R,9S)-3-butyl-3-[(3-carboxypropanoyl)oxy]-8-[(2E)-4-[(3-carboxypropanoyl)oxy]-3-methylbut-2-en-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-3-methylpenta-2,4-dienoic acid IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): above 15 Homo sapiens
(2E,4E)-5-[(2S,3R,6S,8R,9S)-3-butyl-3-[(3-carboxypropanoyl)oxy]-8-[(2E,4E)-6-hydroxy-3-methylhexa-2,4-dien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-3-methylpenta-2,4-dienoic acid IC50 (ng/ml): 560.3. Cell death inducibility of osteoclasts (microgram/ml): not determined Homo sapiens
(2E,4E)-5-[(2S,3R,6S,8R,9S)-3-butyl-3-[(3-carboxypropanoyl)oxy]-8-[(2E,4E,6S,7S)-6,8-dihydroxy-3,7-dimethylocta-2,4-dien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-3-methylpenta-2,4-dienoic acid IC50 (ng/ml): 22.9. Cell death inducibility of osteoclasts (microgram/ml): 6.31 Homo sapiens
(2E,4E)-6-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-9-[(3-carboxypropanoyl)oxy]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-4-methylhexa-2,4-dienoic acid IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): not determined Homo sapiens
(2E,4S,5S,6E,8E)-10-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-3-methyl-9-[(methylsulfanyl)methoxy]-1,7-dioxaspiro[5.5]undec-2-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid IC50 (ng/ml): 497.4. Cell death inducibility of osteoclasts (microgram/ml): 9.6 Homo sapiens
(2E,4S,5S,6E,8E)-10-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-9-hydroxy-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid IC50 (ng/ml): 94.6. Cell death inducibility of osteoclasts (microgram/ml): 11.5 Homo sapiens
(2E,4S,5S,6E,8E)-10-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-9-methoxy-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid IC50 (ng/ml): 57.9. Cell death inducibility of osteoclasts (microgram/ml): not determined Homo sapiens
(2E,4S,5S,6E,8E)-10-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-9-[(3-carboxypropanoyl)oxy]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-4,5-dihydroxy-8-methyldeca-2,6,8-trienoic acid IC50 (ng/ml): 14.4. Cell death inducibility of osteoclasts (microgram/ml): 1.01 Homo sapiens
(2E,4S,5S,6E,8E)-10-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-9-[(4-methoxy-4-oxobutanoyl)oxy]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid IC50 (ng/ml): 292.8. Cell death inducibility of osteoclasts (microgram/ml): 2.5 Homo sapiens
2,3-Dihydro-5-epireveromycin A IC50 (ng/ml): 58.3. Cell death inducibility of osteoclasts (microgram/ml): 0.82 Homo sapiens
2,3-Dihydroreveromycin A IC50 (ng/ml): 11.6. Cell death inducibility of osteoclasts (microgram/ml): 0.22 Homo sapiens
5-acetyl-Reveromycin A IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): 0.46 Homo sapiens
5-Epireveromycin A IC50 (ng/ml): 378.3. Cell death inducibility of osteoclasts (microgram/ml): 21.5 Homo sapiens
5-methoxy-Reveromycin A IC50 (ng/ml): 374. Cell death inducibility of osteoclasts (microgram/ml): above 15 Homo sapiens
5-O-succinyl-Spirofungin A IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): 12.4 Homo sapiens
5-tert-butyl-dimethylsilyl-Reveromycin A IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): 5.9 Homo sapiens
Reveromycin A IC50 (ng/ml): 2.95. Cell death inducibility of osteoclasts (microgram/ml): 0.06 Homo sapiens
Reveromycin A 1-methyl ester IC50 (ng/ml): 211. Cell death inducibility of osteoclasts (microgram/ml): 2 Homo sapiens
Reveromycin A 24-methyl ester IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): 3.1 Homo sapiens
Reveromycin B IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): above 15 Homo sapiens
Spirofungin A IC50 (ng/ml): 564.5. Cell death inducibility of osteoclasts (microgram/ml): above 30 Homo sapiens
Spirofungin B IC50 (ng/ml): value above 1000. Cell death inducibility of osteoclasts (microgram/ml): above 30 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
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 Homo sapiens
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PC-3 cell
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 Homo sapiens
-

Synonyms

Synonyms Comment Organism
IleRS
-
 Homo sapiens
isoleucyl tRNA synthetase
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 Homo sapiens