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Literature summary for 6.1.1.5 extracted from
- Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine (2004), J. Biol. Chem., 279, 8396-8402.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystallization of CP1 domain alone or in complex with L-valine, X-ray structure determination at 1.8 and 2.0 A resolution respectively, and analysis | Thermus thermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-isoleucine + tRNAIle | Thermus thermophilus | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermus thermophilus | P56690 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle | editing and substrate recognition and binding mechanism, important involved residues are Asp238, Thr228, Thr229, and Thr230 | Thermus thermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-isoleucine + tRNAIle | - |
Thermus thermophilus | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
r | |
| ATP + L-valine + tRNAIle | - |
Thermus thermophilus | AMP + diphosphate + L-valyl-tRNAIle | CP1 domain of the enzyme deacylates or edits the mischarged Val-tRNAIle | r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IleRS | - |
Thermus thermophilus |
| IRS | - |
Thermus thermophilus |
| Isoleucine translase | - |
Thermus thermophilus |
| Isoleucine--tRNA ligase | - |
Thermus thermophilus |
| Isoleucine-transfer RNA ligase | - |
Thermus thermophilus |
| Isoleucine-tRNA synthetase | - |
Thermus thermophilus |
| Isoleucyl-transfer ribonucleate synthetase | - |
Thermus thermophilus |
| Isoleucyl-transfer RNA synthetase | - |
Thermus thermophilus |
| Isoleucyl-tRNA synthetase | - |
Thermus thermophilus |
| Mupirocin resistance protein | - |
Thermus thermophilus |
| Synthetase, isoleucyl-transfer ribonucleate | - |
Thermus thermophilus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Thermus thermophilus | |
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