Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ethyl monate-A | - |
Staphylococcus aureus | |
Ile-NHSO2-AMP | non-hydrolyzable reaction intermediate analogue, slow-tight binding, competitive and inhibition mechanism, reversible | Staphylococcus aureus | |
isoleucinyl-adenylate | i.e. Ile-ol-AMP, non-hydrolyzable reaction intermediate analogue, slow-tight binding, competitive and inhibition mechanism, reversible | Staphylococcus aureus | |
pseudomonic acid | forms a non-hydrolyzable reaction intermediate analogue, competitive inhibition | Staphylococcus aureus | |
SB-205952 | a semisynthetic analogue of monic acid, possesing a nitrofuryl chromophore | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-isoleucine + tRNAIle | Staphylococcus aureus | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-isoleucine + tRNAIle | - |
Staphylococcus aureus | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
r | |
additional information | enzyme also performs the reversible ATP-diphosphate exchange reaction | Staphylococcus aureus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IleRS | - |
Staphylococcus aureus |
IRS | - |
Staphylococcus aureus |
Isoleucine translase | - |
Staphylococcus aureus |
Isoleucine--tRNA ligase | - |
Staphylococcus aureus |
Isoleucine-transfer RNA ligase | - |
Staphylococcus aureus |
Isoleucine-tRNA synthetase | - |
Staphylococcus aureus |
Isoleucyl-transfer ribonucleate synthetase | - |
Staphylococcus aureus |
Isoleucyl-transfer RNA synthetase | - |
Staphylococcus aureus |
Isoleucyl-tRNA synthetase | - |
Staphylococcus aureus |
Mupirocin resistance protein | - |
Staphylococcus aureus |
Synthetase, isoleucyl-transfer ribonucleate | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus aureus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Staphylococcus aureus | |
0.000003 | - |
Ile-NHSO2-AMP | pH 7.9, 22°C | Staphylococcus aureus | |
0.00002 | - |
pseudomonic acid | pH 7.9, 22°C | Staphylococcus aureus | |
0.00004 | - |
ethyl monate-A | pH 7.9, 22°C | Staphylococcus aureus | |
0.000045 | - |
SB-205952 | pH 7.9, 22°C | Staphylococcus aureus | |
0.00009 | - |
isoleucinyl-adenylate | pH 7.9, 22°C | Staphylococcus aureus |